This hot chicken casserole is filled with cheese, spinach, artichoke hearts and more. The epitome of comfort food, just right for cozy nights in.

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Looking for a new hearty casserole? Look no further, this one is for you! This Spinach Artichoke Chicken Casserole is going to be everyone’s new favorite dinner recipe.

This chicken casserole is stuffed with 3 cheeses, chicken, artichoke hearts, spinach, and more! Baked up creamy and hot in the oven, it might just be the perfect comfort food.

Chicken and spinach casserole in a white dish with a spoon.

Made for a crowd!

This recipe makes 10-12 servings. It’s perfect for a houseful of kids or a potluck party dish.

Or, if you love meal prepping, this is a recipe you’re going to want to make. You can feed a family of four AND have several lunches worth of chicken casserole left over for lunches.

Make This a True One-Pan Dinner

If you’re into LESS dirty dishes. Then you should know this casserole can be mixed right in the baking dish. It’s a tight fit, but you can get it in there and stir it together if you’re careful. But being careful will result in less dishes. So go for it, if you want!

A bowl of chicken, spinach, and cheese in a white bowl.

What You Need to Make this Chicken Casserole

This recipe calls for lots of cheese and dairy products but nothing to out of the ordinary. Add these ingredients to your shopping list, and be ready to make a casserole that everyone will love!

Cream Cheese
Sour Cream
Parmesan Cheese
Monterey Jack Cheese
Garlic
Onion
Salt
Pepper
Cooked Chicken (use leftover roasted chicken or any other cooked chicken)
Artichoke Hearts
Spinach

Chicken and spinach casserole in white bowls with a spoon.

Let’s Break Down the Ingredients for this Spinach Artichoke Chicken Casserole

I have a few notes on the ingredients to help you grab the right things at the store.

The spinach is fresh spinach, cleaned and chopped. You can swap out the fresh spinach for frozen chopped spinach. Just let it thaw, drain it, and add it in!

The chicken is cooked chicken, if you have any leftover chicken or even even turkey you can use it here. Rotisserie chicken is perfect here, too. If you’re in a pinch try my air fryer grilled chicken to use in this recipe.

Look for artichoke hearts that are not pickled. You can use pickled hearts, but the flavor will take over your casserole. Not that it’s a bad thing, but it changes it.

Other Casseroles We Love!

This Chicken Fajita Casserole is top notch and SO easy to make too! Or try this Crock Pot Chicken and Rice Casserole. Need one more idea? Try this Chicken Bacon Ranch Tater Tot Casserole. Oh so delish!

Chicken and spinach casserole in a white dish with a fork.

Change Up This Recipe!

Add red pepper flakes or sriracha if you love a little kick. Or salsa would be fun too! If you want to change up your cheeses, try adding sharp cheddar or pepper jack for a change.

Got Leftovers?

You’re in luck! This casserole tastes BETTER the next day. The flavors have melded more overnight, and things just taste better that way.

Store leftovers in an airtight container for up to three days. You can reheat this chicken casserole OR eat it cold. Try in a tortilla with lettuce as a wrap. That is an easy, tasty lunch right there.